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XOCOVA (ensitrelvir) 125 mg tablets logo

How to take XOCOVA

For people aged 12 years and older, start XOCOVA as soon as possible, within 3 days (72 hours) of being exposed to someone with COVID‑19.

Take three XOCOVA pills together on Day 1 followed by one XOCOVA pill on Days 2 through 5. Take XOCOVA at about the same time each day with or without food.

COVID‑19=coronavirus disease 2019.

A woman holding a XOCOVA pill and a glass of water

Not actual pill size.

XOCOVA starts blocking the COVID-19 virus when taken after COVID-19 exposure

An icon of the COVID-19 virus

Take XOCOVA for 5 days

Take three XOCOVA pills together on Day 1 followed by one XOCOVA pill on Days 2 through 5. Take XOCOVA at about the same time each day with or without food.

Do not stop taking XOCOVA without talking to your healthcare professional.

XOCOVA comes in a blister pack containing 7 pills. Do not remove XOCOVA pills from the blister pack until you are ready to take your dose.

An illustration of the dosing schedule, with 3 pills on Day 1 and one pill on Days 2-5

Not actual pill size.

Be prepared to make the call

Whether you're attending a crowded event like a wedding or going on a family trip, be ready for when COVID‑19 exposure happens.

Be prepared by proactively speaking with your healthcare professional about XOCOVA.

Download the XOCOVA Discussion Guide

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See who you can ask about XOCOVA

What is XOCOVA?

XOCOVA (ensitrelvir) is a prescription medicine used to help prevent coronavirus disease 2019 (COVID‑19) in adults and children aged 12 years and older following contact with a person who has COVID‑19 (post-exposure prophylaxis). It is not known if XOCOVA is safe and effective in children under age 12.

Important Safety Information and Use

Do not take XOCOVA if you:

  • are allergic to ensitrelvir or any of the ingredients in XOCOVA.
  • take any of the following medicines, as these may interact with XOCOVA and may cause severe or life-threatening side effects or death:
    • apalutamide
    • carbamazepine
    • colchicine
    • dihydroergotamine
    • enzalutamide
    • eplerenone
    • ergotamine
    • finerenone
    • ivabradine
    • lomitapide
    • lumacaftor/ivacaftor
    • lurasidone
    • methylergonovine
    • phenytoin
    • pimozide
    • quinidine
    • rifampin
    • St John’s wort
    • simvastatin
    • triazolam
    • voclosporin

    These are not the only medicines that may cause serious or life-threatening side effects if taken with XOCOVA. XOCOVA may increase or decrease the levels of many medicines in your body. Tell your healthcare provider (HCP) about all the medicines you take because additional laboratory tests or dose changes of your other medicines may be necessary during XOCOVA use. Your HCP may tell you about specific symptoms to watch for that may indicate you need to stop or decrease the dose of some of your other medicines.

Before taking XOCOVA, tell your HCP about all your medical conditions, including if you:

  • are pregnant or plan to become pregnant. XOCOVA may harm your unborn baby. For females who are able to become pregnant, your HCP will check with you to see if you are pregnant before starting XOCOVA. Use effective birth control (contraception) during XOCOVA use and for 2 weeks after the final dose. Tell your HCP right away if you become pregnant or think you may be pregnant during XOCOVA use.
  • are breastfeeding or plan to breastfeed. It is not known if XOCOVA passes into your breast milk. Do not breastfeed during XOCOVA use and for 2 weeks after the final dose.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Your HCP can tell you if it is safe to take XOCOVA with other medicines. Do not start a new medicine without telling your HCP.

What are the possible side effects of XOCOVA?

XOCOVA may cause serious side effects, including:

  • Allergic reactions, including severe allergic reactions (anaphylaxis). Stop taking XOCOVA and get medical help right away if you get any of the following allergic reaction symptoms: skin rash; hives; itching; swelling of the mouth, lips, tongue, or face; trouble swallowing or breathing; throat tightness; dizziness or feeling lightheaded; stomach-area (abdomen) pain; or vomiting.

The most common side effects of XOCOVA include: headache, diarrhea, and cough.

These are not all possible side effects of XOCOVA. For more info, ask your HCP or pharmacist. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information, for XOCOVA.